🚀 Where single molecule meets high throughput - power the next generation of molecular and drug discovery with the EI-FLEX Pro

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Delineation of a novel assembly intermediate in Rous sarcoma virus integration pathway
EI-FLEX data revealed a transient tetrameric intermediate in retroviral DNA integration.
Application note – Monitoring biomolecular conformational dynamics with the EI-FLEX system: A quantitative smFRET approach
Discover how smFRET can capture conformational dynamics on the EI-FLEX Pro using a DNA hairpin model system, measuring the influence of salt on opening and closing rates.
Beyond the average: The EI-FLEX Pro makes high-throughput single-molecule assays industry-ready
In this press release, we announce the launch of the EI-FLEX Pro and EI-FLEX Pro HT, bringing automated, high-throughput single-molecule analysis to the benchtop and enabling industry-ready workflows across drug discovery, biotech, and academic research.
Application note – Measuring nanoscale distances with single-molecule FRET on the EI-FLEX system
In this application note, we demonstrate how single-molecule FRET can be used to measure nanoscale distances on the EI-FLEX system using a model DNA duplex.
Technical note – Capturing accurate single-molecule FRET measurements on the EI-FLEX platform
In this technical note, we explore several key components of a confocal FRET experiment that ensure single-molecule sensitivity and accurate determination of FRET efficiencies during acquisition and analysis.
Mastering smFRET: A practical handbook for researchers
Discover everything you need to understand single-molecule FRET and use it to advance your research. Download the handbook now.
Electronic actuation of surface-immobilised, pH-responsive DNA nanoswitches
Discover how EI-FLEX smFRET reveals pH-driven DNA triplex nanoswitching and confirms that dynamic DNA machines retain fast, reversible conformational control even when densely immobilised on electronic surfaces.
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.
Precision and accuracy of single-molecule FRET measurements
Discover how the landmark Hellenkamp et al. study set the standard for precise, reproducible single-molecule FRET measurements using DNA rulers.
Illuminating the Invisible
Discover a showcase of pioneering single-molecule fluorescence studies redefining molecular science.
Recognition of gapped DNA by DNA polymerase
Explore EI-FLEX data from the University of Sheffield uncovering how DNA polymerase I identifies gapped DNA through substrate bending and dynamic conformations.