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  • Application note (13)
  • Article (10)
  • Paper (10)
  • Preprint (5)
  • Ebook (4)
  • Press Release (4)
  • Technical note (3)
  • Webinar (2)
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Applications
  • Protein structure and dynamics (36)
  • Enzymes (30)
  • DNA structure (29)
  • Protein-DNA interactions (29)
  • Protein-RNA interactions (28)
  • Replication (28)
  • Membrane proteins and receptors (27)
  • RNA structure (26)
  • Disordered proteins (25)
  • DNA repair (24)
  • Antibody-ligand interactions (23)
  • Molecular motors (22)
  • Quadruplexes / higher order structures (22)
  • Transcription (22)
  • DNA organisation (21)
  • DNA origami (21)
  • Riboswitches (21)
  • Ternary complexes, protacs, glues (21)
  • DNA editing (19)
  • Phase separation (19)
  • Protein aggregation (19)
  • R-loops (19)
  • Chromatin (18)
  • PTM detection (18)

Technology

Technology
  • smFRET (40)
  • FCS (15)
  • FCCS (11)

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Delineation of a novel assembly intermediate in Rous sarcoma virus integration pathway
EI-FLEX data revealed a transient tetrameric intermediate in retroviral DNA integration.
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Discover EI-FLEX data revealing amino acid sensing in eukaryotic cells.
A universal protein ladder for standardisation of diverse FRET assays
Learn how researchers used a universal protein FRET ladder to calibrate FRET measurements across EI-FLEX, FLIM-FRET and flow cytometry.
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
See how smFRET reveals the heterogeneous conformational landscape of Kinesin-1 and how ionic conditions regulate motor protein activity.
Electronic actuation of surface-immobilised, pH-responsive DNA nanoswitches
Discover how EI-FLEX smFRET reveals pH-driven DNA triplex nanoswitching and confirms that dynamic DNA machines retain fast, reversible conformational control even when densely immobilised on electronic surfaces.
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
Discover how single-molecule FRET data on the EI-FLEX helped to uncover two previously hidden intermediate conformational states of a bacterial Rep helicase, overcoming surface-induced artefacts to reveal its dynamic mechanism in action.
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.

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