Discover how EI-FLEX smFRET reveals pH-driven DNA triplex nanoswitching and confirms that dynamic DNA machines retain fast, reversible conformational control even when densely immobilised on electronic surfaces.
Discover how single-molecule FRET data on the EI-FLEX helped to uncover two previously hidden intermediate conformational states of a bacterial Rep helicase, overcoming surface-induced artefacts to reveal its dynamic mechanism in action.
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
