Unlocking the ultimate
single-molecule resolution

For life science research, drug development
and clinical diagnostics​

Exciting Instruments
Single-molecule fluorescence technology

From complexity to clarity

A new way to gather dynamic single-molecule data — the EI-FLEX system

Generate high-impact insights into biomolecular interactions and dynamics. Capture transient intermediates and molecular heterogeneity directly in solution to strengthen your next publication or grant.

Application Benefits Explorer
What you can use it for

Turn molecular complexity into
measurable insight

Powered by single-molecule precision: smFRET, FCS and FCCS in one integrated platform

The Transformation - Exciting Instruments
Challenges › Solutions

When powerful technology becomes accessible,
scientific progress accelerates

Traditional Approach

Limited access to dynamic molecular insight

  • Structural and bulk methods primarily report static or averaged states, obscuring heterogeneity and transient behaviour
  • Single-molecule experiments typically require large, specialised, or custom-built infrastructure, inaccessible to the broader community
  • Experimental possibilities are constrained by available infrastructure rather than scientific questions
  • Complex workflows to set up, maintain and use instruments prevent adoption by non-technical scientists
  • Data analysis is based on custom, specialised data analysis workflows that depend on individual coding skills and legacy analysis scripts
EI-FLEX

Routine access to single-molecule dynamics and interactions, directly in solution

  • Direct observation of molecular dynamics and conformational heterogeneity under physiologically relevant conditions
  • Benchtop platform enabling single-molecule measurements directly in solution
  • Guided alignment, data acquisition, and integrated analysis lower the barrier to high-quality experiments
  • Multiple single-molecule methods accessible within a single, unified experimental framework
  • Reproducible, reliable single-molecule data across projects, users, and laboratories
Founder Quote – Exciting Instruments
Our mission
Dr. Timothy Craggs
Across research and drug discovery, critical decisions are often made with incomplete insight – rare states are averaged out, transient behaviours are missed, and uncertainty slows progress.

Our mission is to change that. We exist to offer true single-molecule sensitivity – the ultimate resolution, at the moment it matters, so teams can quickly move from assumptions to understanding, and from risk to confidence.

By removing the barriers that once limited access to high-resolution dynamic insight, we enable researchers – in academia and industry alike – to ask better questions, resolve complexity earlier, and accelerate the journey from discovery to real-world impact.

Dr. Timothy Craggs

Founder and CEO, Exciting Instruments

Meet our management team

Trusted by

"This opens up a range of research for us that was previously impossible."

Dr. Steven Quinn, University of York