Pushing the boundaries of single-molecule science
Discover how leading academics are using single-molecule fluorescence spectroscopy to further their research in this collection of case studies
Download your single-molecule fluorescence spectroscopy ebook as a practical resource and source of inspiration
Discover single-molecule research from leading academics
This 65-page ebook brings together a series of expert-led seminars from our community, each showcasing how single-molecule spectroscopy is being used in practice to answer meaningful biophysical questions.
You’ll find:
- Sophisticated methodological insights from pioneers like Shimon Weiss, Thorben Cordes, Elizabeth Rhoades and Nicole Robb
- Translational case studies on proteins like tau, alpha-synuclein, and SARS-CoV-2 polymerase
- Cutting-edge data analysis strategies using open-source tools like FRETBursts and H2MM
- A view into the future of single-molecule science – where high-throughput screening, live-cell imaging, and AI-driven modelling are already on the horizon
Download now to discover the impact of single-molecule fluorescence spectroscopy, how it can be used in your own research, and a glimpse into what the future may hold.
Featured academics and research topics
From Concept to Canon: The Evolution and Future of Single-Molecule FRET
Three-colour Single-Molecule FRET:
Unlocking Dynamic Complexity in Molecular
Machines
Mastering Confocal smFRET Analysis: Burst
Detection, H2MM modelling, and Robust
Assay Interpretation
From Accurate FRET to Assay Design: A Quantitative Roadmap for Protein
Conformational Studies
Probing Functional Mechanisms of
Intrinsically Disordered Proteins Using FCS:
Insights into Tau and Alpha-Synuclein
Decoding Membrane Protein Pharmacology
Using Fluorescence Correlation
Spectroscopy: From Model Cell Lines to
Native Contexts
Decoding the Dynamic Architecture of Replication Protein A (RPA): Insights from Multi-Domain Biophysics and Single-
Molecule Studies
Deciphering SARS-CoV-2 Polymerase Activity Using Single-Molecule FRET:
Mechanisms of RNA Replication and
Inhibition
Exploring Nucleic Acid Flexibility and RNA-Protein Interactions with smFRET: Insights from DNA Hairpins and Viral mRNA Elements
Curious about benchtop smFRET and FCS?
Unlock your research potential and speed to publication with Exciting Instruments’ benchtop single-molecule fluorescence spectrometer.
Functions in ambient line, without an optical table or dark room and without the need for extensive, expert-level training.