What exactly is single-molecule FRET?

Watch our founder and CEO, Tim Craggs, explain this powerful technique and how it measures nanometer-scale distances and captures protein or nucleic acid conformations one molecule at a time – no ensemble averaging needed.

Check out the worldwide benchmark study on the precision and accuracy of single-molecule FRET measurements (which we led with Thorsten Fugel, Klaus Seidl and Jens Michaelis) here.

Our EI-FLEX benchtop instrument combines precision and ease-of-use, turning 50 years of expertise into “a professor in a box” with automated analysis and cloud archiving.

From GPCR conformations to protein–nucleic acid interactions, smFRET is transforming structural biology and drug discovery. ✨