Discover everything you need to understand fluorescence correlation spectroscopy (FCS) and fluorescence cross-correlation spectroscopy (FCCS) and use it to advance your research. Download the handbook now.
In traditional drug discovery, we have long been settling for the average. Explore how single-molecule clarity de-risks biopharma pipelines, targets undruggable IDPs, and powers lab-in-the-loop AI discovery.
Discover how smFRET on the EI-FLEX reveals pH-driven DNA triplex nanoswitching, identifying the pH values at which full switching occurs, or heterogeneous populations are present.
In this application note, we explore how smFRET was used on the EI-FLEX to uncover two additional conformational states in the bacterial helicase Rep, expanding on previously defined structures.
Explore how smFRET and FCS can reveal the mechanism of action of two SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors using a doubly labelled RNA hairpin as a reporter for RNA extension.
Static models only tell half the story. Here, we explore the critical importance of capturing biomolecular dynamics and how mapping these movements links structure to true biological function.
To ensure calculated distances are accurate and relate to the physical positions of the labelled biomolecules of interest, we discuss the importance of data correction and additional modelling in this technical note.
