In this article, we explore how the 'messy middle' of biophysics, namely crude lysates and serum, combines single-molecule sensitivity with biological context.
In traditional drug discovery, we have long been settling for the average. In this article, we explore how single-molecule clarity de-risks biopharma pipelines, targets undruggable IDPs, and powers lab-in-the-loop AI discovery.
Discover how smFRET on the EI-FLEX reveals pH-driven DNA triplex nanoswitching, identifying the pH values at which full switching occurs, or heterogeneous populations are present.
