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EI-FLEX
Technology
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Home
EI-FLEX
Technology
Applications
Resources
Resource Library
About
Management
Careers
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Resource Library
19 December 2025
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Author
Jessica May Price
Format
Paper
Groves et al.
Nucleic Acids Research
, Volume 53, Issue 8, 8 May 2025, gkaf351,
https://doi.org/10.1093/nar/gkaf351
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Tags
Customer data
,
Delayed termination
,
EI-FLEX
,
Molecular motors
,
Polymerase stalling
,
Protein–RNA interactions
,
Replication
,
RNA polymerase
,
Single-molecule kinetics
,
smFRET
,
Transcription
Technology
smFRET
Applications
Protein structure and dynamics
Replication
Protein-RNA interactions
RNA structure
Enzymes
Enzymes
Recent posts
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
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Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.
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Precision and accuracy of single-molecule FRET measurements
Discover how the landmark Hellenkamp et al. study set the standard for precise, reproducible single-molecule FRET measurements using DNA rulers.
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