“Recently awarded the Kazuhiko Kinosita Award at BPS 2022 in recognition of their contributions to the field of single-molecule biophysics, Professor Shimon Weiss is a pioneer in the development of single-molecule fluorescence detection techniques and their application to study motor protein orientations and dynamics.

In this episode of Exciting Seminars, Shimon discusses:

• Origins and breakthroughs: The pioneering story of single-molecule FRET, born from curiosity, chance encounters, and bold experimentation
• Scientific journey: A personal and historical narrative of invention, moving from physics and engineering roots into biophysics
• Transformative tool: How smFRET became a molecular ruler, unlocking dynamic structural biology beyond static snapshots
• Applications and impact: From transcription mechanics to super-resolution, diagnostics, and live-cell measurements, reshaping how we see molecular machines
• Future and vision: Expanding into multi-colour, high-throughput, and solution-based methods, ensuring smFRET remains central in biology’s next breakthroughs”