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Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
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Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.
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Precision and accuracy of single-molecule FRET measurements
Discover how the landmark Hellenkamp et al. study set the standard for precise, reproducible single-molecule FRET measurements using DNA rulers.
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Delineation of a novel assembly intermediate in retroviral integration pathway
EI-FLEX data revealed a transient tetrameric intermediate in retroviral DNA integration.
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Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Discover EI-FLEX data revealing amino acid sensing in eukaryotic cells.
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Three-colour single molecule FRET
Discover how Prof. Thorsten Hugel uses three-colour smFRET to explore protein structure, dynamics, and molecular machines in real time.
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Rapid antibody fragment production and binding analysis
Discover EI-FLEX data showcasing a method for rapid production of antibody fragments using FCS.
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A new protein-dependent riboswitch activates ribosomal frameshifting
Discover EI-FLEX data illuminating new principles of RNA structure, translation, and regulation from the University of York.
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Rigby (raised $500M+, led Nasdaq IPOs) appointed Chair of Exciting Instruments
Exciting Instruments has announced the appointment of Jonathan Rigby as Chairman of its Board of Directors.
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Illuminating the Invisible
Discover a showcase of pioneering single-molecule fluorescence studies redefining molecular science.
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An introduction to smFRET
Watch our CEO and founder Tim give a short but sweet introduction to freely diffusing smFRET in this explainer video.
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spFRET/smFRET – a story of tools making
Watch Professor Shimon Weiss (UCLA), inventor of ALEX and pioneer of smFRET, in his Exciting Seminar.
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