Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.
Precision and accuracy of single-molecule FRET measurements
Discover how the landmark Hellenkamp et al. study set the standard for precise, reproducible single-molecule FRET measurements using DNA rulers.
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Discover EI-FLEX data revealing amino acid sensing in eukaryotic cells.
Three-colour single molecule FRET
Discover how Prof. Thorsten Hugel uses three-colour smFRET to explore protein structure, dynamics, and molecular machines in real time.
Rapid antibody fragment production and binding analysis
Discover EI-FLEX data showcasing a method for rapid production of antibody fragments using FCS.
A new protein-dependent riboswitch activates ribosomal frameshifting
Discover EI-FLEX data revealing a protein-dependent RNA riboswitch that controls ribosomal frameshifting.
Rigby (raised $500M+, led Nasdaq IPOs) appointed Chair of Exciting Instruments
Exciting Instruments has announced the appointment of Jonathan Rigby as Chairman of its Board of Directors.
Illuminating the Invisible
Discover a showcase of pioneering single-molecule fluorescence studies redefining molecular science.
An introduction to smFRET
Watch our CEO and founder Tim give a short but sweet introduction to freely diffusing smFRET in this explainer video.
spFRET/smFRET – a story of tools making
Watch Professor Shimon Weiss (UCLA), inventor of ALEX and pioneer of smFRET, in his Exciting Seminar.
Recognition of gapped DNA by DNA polymerase
Explore EI-FLEX data from the University of Sheffield uncovering how DNA polymerase I identifies gapped DNA through substrate bending and dynamic conformations.