In this application note, we explore how smFRET was used on the EI-FLEX to uncover two additional conformational states in the bacterial helicase Rep, expanding on previously defined structures.
Explore how smFRET and FCS can reveal the mechanism of action of two SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors using a doubly labelled RNA hairpin as a reporter for RNA extension.