Delineation of a novel assembly intermediate in Rous sarcoma virus integration pathway
EI-FLEX data revealed a transient tetrameric intermediate in retroviral DNA integration.
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Discover how EI-FLEX smFRET reveals pH-driven DNA triplex nanoswitching and confirms that dynamic DNA machines retain fast, reversible conformational control even when densely immobilised on electronic surfaces.
Beyond the average: The EI-FLEX Pro makes high-throughput single-molecule assays industry-ready
In this press release, we announce the launch of the EI-FLEX Pro and EI-FLEX Pro HT, bringing automated, high-throughput single-molecule analysis to the benchtop and enabling industry-ready workflows across drug discovery, biotech, and academic research.
Mastering smFRET: A practical handbook for researchers
Discover everything you need to understand single-molecule FRET and use it to advance your research. Download the handbook now.
Electronic actuation of surface-immobilised, pH-responsive DNA nanoswitches
Discover how EI-FLEX smFRET reveals pH-driven DNA triplex nanoswitching and confirms that dynamic DNA machines retain fast, reversible conformational control even when densely immobilised on electronic surfaces.
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
Discover how single-molecule FRET data on the EI-FLEX helped to uncover two previously hidden intermediate conformational states of a bacterial Rep helicase, overcoming surface-induced artefacts to reveal its dynamic mechanism in action.
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Discover how smFRET data from EI-FLEX visualises real-time RNA synthesis by SARS-CoV-2 RdRp and reveals how antiviral inhibitors remodel polymerase dynamics to halt viral replication.
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Discover how smFRET data from the EI-FLEX reveals how RPA partially wraps single-stranded DNA and remodels its structure through phosphorylation.
Precision and accuracy of single-molecule FRET measurements
Discover how the landmark Hellenkamp et al. study set the standard for precise, reproducible single-molecule FRET measurements using DNA rulers.
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
Discover EI-FLEX data revealing amino acid sensing in eukaryotic cells.
Three-colour single molecule FRET
Discover how Prof. Thorsten Hugel uses three-colour smFRET to explore protein structure, dynamics, and molecular machines in real time.
Rapid antibody fragment production and binding analysis
Discover EI-FLEX data showcasing a method for rapid production of antibody fragments using FCS.