In traditional drug discovery, we have long been settling for the average. In this article, we explore how single-molecule clarity de-risks biopharma pipelines, targets undruggable IDPs, and powers lab-in-the-loop AI discovery.
Discover how smFRET on the EI-FLEX reveals pH-driven DNA triplex nanoswitching, identifying the pH values at which full switching occurs, or heterogeneous populations are present.
In this application note, we explore how smFRET was used on the EI-FLEX to uncover two additional conformational states in the bacterial helicase Rep, expanding on previously defined structures.
